Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase

Med Sci (Paris). 2018 Oct:34 Focus issue F1:4-7. doi: 10.1051/medsci/201834f101. Epub 2018 Nov 7.

Abstract

Objective: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China.

Methods: In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed.

Results: LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabetic mice with LWDH extract decreased camp, fasting blood glucose, TC, TG, LDL-c, HbA1C, Urine volume levels and Urine sugar, increased HDL-c level when compared to STZ induced diabetic mice.

Conclusion: This study demonstrates that extract of LWDH can inhibit α-amylase and α-glucosidase activities and shows anti-diabetic effect in a mice preclinical model.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / chemically induced
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Drugs, Chinese Herbal / pharmacology*
  • Enzyme Inhibitors / pharmacology*
  • Female
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Hypoglycemic Agents / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Streptozocin
  • alpha-Amylases / antagonists & inhibitors*
  • alpha-Amylases / metabolism
  • alpha-Glucosidases / metabolism

Substances

  • Drugs, Chinese Herbal
  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents
  • Liuwei Dihuang Decoction
  • Streptozocin
  • alpha-Amylases
  • alpha-Glucosidases