Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients

Pharmacotherapy. 2018 Dec;38(12):1260-1266. doi: 10.1002/phar.2194. Epub 2018 Nov 26.

Abstract

Background: Infections with adenoviruses (ADVs) can result in considerable mortality and morbidity in solid organ transplant (SOT) recipients. Standard therapy for ADV infections in transplant recipients is not established. At our institution, intravenous cidofovir and immunoglobulin have been used to treat disseminated or invasive ADV in SOT and hematopoietic stem cell transplant recipients.

Methods: A retrospective case series of SOT recipients treated with cidofovir and intravenous immunoglobulin was performed.

Results: Five SOT recipients (four renal and one heart transplant) with adenovirus infection were treated successfully with cidofovir and immunoglobulin. Cidofovir was discontinued after the first negative ADV viral load and resolution of clinical symptoms, given the concern for nephrotoxicity in renal transplant recipients. Renal tubular acidosis type 2 and iritis were observed in two patients receiving therapy.

Conclusion: Symptom resolution and a single negative ADV viral load may be indicators for cidofovir discontinuation.

Keywords: adenovirus; cidofovir; intravenous immunoglobulin; solid organ transplant.

MeSH terms

  • Adenoviridae Infections / diagnosis
  • Adenoviridae Infections / drug therapy*
  • Adult
  • Aged
  • Aged, 80 and over
  • Antiviral Agents / administration & dosage*
  • Cidofovir / administration & dosage*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Immunologic Factors / administration & dosage*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Transplant Recipients*
  • Treatment Outcome
  • Viral Load / drug effects
  • Viral Load / physiology

Substances

  • Antiviral Agents
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Cidofovir

Associated data

  • GENBANK/NCT01241344