Effect of Race on Outcomes Following Early Coronary Computed Tomographic Angiography or Standard Emergency Department Evaluation for Acute Chest Pain

Ethn Dis. 2018 Oct 18;28(4):517-524. doi: 10.18865/ed.28.4.517. eCollection Fall 2018.


Objective: To examine racial differences in outcomes with coronary computed tomographic angiography (CCTA) vs standard emergency department (ED) evaluation for chest pain.

Design: Retrospective analysis of the prospective, randomized, multicenter Rule Out Myocardial Ischemia/Infarction by Computer Assisted Tomography (ROMICAT-II) trial.

Setting: ED at nine hospitals in the United States.

Participants: 940 patients who were Caucasian or African American (AA) presenting to the ED with chest pain.

Interventions: CCTA or standard ED evaluation.

Main outcome measures: Length of stay, hospital admission, direct ED discharge, downstream testing and repeat ED visit or hospitalization for recurrent chest pain at 28 days. Safety end points: missed acute coronary syndrome (ACS) and cumulative radiation exposure during the index visit and follow-up period.

Results: 659 (66%) patients self-identified as Caucasian and 281 (28%) self-identified as AA. AA were younger and more often female compared with Caucasians, had a higher prevalence of hypertension (64% vs 49%, P<.001) and diabetes (23% vs 14%, P<.001) and a lower prevalence of hyperlipidemia (28% vs 51%, P<.001). ACS was more frequent among Caucasians (10% vs 2%, P<.001). Randomization to CCTA resulted in a reduction in median LOS for Caucasians (7.4 vs 24.7 hours, P<.001) and AA (8.9 vs. 26.3, P<.001; P-interaction=.88). Both AA and Caucasian patients experienced greater radiation exposure and more downstream testing with CCTA compared with standard evaluation.

Conclusions: Early CCTA reduced median LOS for both AA and Caucasian patients presenting to the ED with chest pain by approximately 17 hours compared with standard evaluation.

Trial registration: ClinicalTrials.gov NCT01084239.

Keywords: Acute Coronary Syndromes; Cardiac Computed Tomography; Chest Pain; Emergency Department; Ethnicity/Race.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acute Coronary Syndrome* / diagnosis
  • Acute Coronary Syndrome* / ethnology
  • Acute Coronary Syndrome* / physiopathology
  • African Americans / statistics & numerical data
  • Chest Pain* / diagnosis
  • Chest Pain* / ethnology
  • Chest Pain* / etiology
  • Computed Tomography Angiography / methods*
  • Coronary Angiography / methods
  • Coronary Artery Disease* / diagnosis
  • Coronary Artery Disease* / ethnology
  • Coronary Artery Disease* / physiopathology
  • Early Diagnosis
  • Emergency Service, Hospital / statistics & numerical data
  • European Continental Ancestry Group / statistics & numerical data
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • United States / epidemiology

Associated data

  • ClinicalTrials.gov/NCT01084239