Emerging Roles of Fibroblast Growth Factor 10 in Cancer

Front Genet. 2018 Oct 24:9:499. doi: 10.3389/fgene.2018.00499. eCollection 2018.


Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Factor 10 (FGF10) has been implicated in multiple cancers, including breast, prostate and pancreatic ductal adenocarcinoma. Here, we examine the mechanisms underlying FGF10-induced tumourigenesis and explore novel approaches to target FGF10 signaling in cancer.

Keywords: FGF10; FGFR1; FGFR1b; FGFR2; FGFR2b; cancer.