Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Yi Huang; Pan Li; Xiu-Qin Dong; Xumu Zhang

doi:10.1039/c8ob02231c

Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Org Biomol Chem. 2018 Nov 21;16(45):8819-8823. doi: 10.1039/c8ob02231c.

Authors

Yi Huang¹, Pan Li, Xiu-Qin Dong, Xumu Zhang

Affiliation

¹ Key Laboratory of Biomedical Polymers, Engineering Research Centre of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. zhangxm@sustc.edu.cn xiuqindong@whu.edu.cn.

PMID: 30406248
DOI: 10.1039/c8ob02231c

Abstract

Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).

Publication types

Research Support, Non-U.S. Gov't