Challenges in the Use of Compact Disc-Based Centrifugal Microfluidics for Healthcare Diagnostics at the Extreme Point of Care

Jordon Gilmore; Monsur Islam; Rodrigo Martinez-Duarte

doi:10.3390/mi7040052

Challenges in the Use of Compact Disc-Based Centrifugal Microfluidics for Healthcare Diagnostics at the Extreme Point of Care

Micromachines (Basel). 2016 Mar 24;7(4):52. doi: 10.3390/mi7040052.

Authors

Jordon Gilmore¹, Monsur Islam², Rodrigo Martinez-Duarte³

Affiliations

¹ Mechanical Engineering Department, Clemson University, Clemson, SC 29634, USA. jagilmo@clemson.edu.
² Mechanical Engineering Department, Clemson University, Clemson, SC 29634, USA. monsuri@g.clemson.edu.
³ Mechanical Engineering Department, Clemson University, Clemson, SC 29634, USA. rodrigm@clemson.edu.

Abstract

Since its inception, Compact Disc (CD)-based centrifugal microfluidic technology has drawn a great deal of interest within research communities due to its potential use in biomedical applications. The technology has been referred to by different names, including compact-disc microfluidics, lab-on-a-disk, lab-on-a-CD and bio-disk. This paper critically reviews the state-of-the-art in CD-based centrifugal microfluidics devices and attempts to identify the challenges that, if solved, would enable their use in the extreme point of care. Sample actuation, manufacturing, reagent storage and implementation, target multiplexing, bio-particle detection, required hardware and system disposal, and sustainability are the topics of focus.

Keywords: centrifugal; diagnostic; lab-on-disk; microfluidics; point of care.

Publication types

Review