Inflamed Astrocytes: A Path to Depression Led by Menin

Fernanda Neutzling Kaufmann; Caroline Menard

doi:10.1016/j.neuron.2018.10.039

Inflamed Astrocytes: A Path to Depression Led by Menin

Neuron. 2018 Nov 7;100(3):511-513. doi: 10.1016/j.neuron.2018.10.039.

Authors

Fernanda Neutzling Kaufmann¹, Caroline Menard²

Affiliations

¹ Department of Psychiatry and Neuroscience, Faculty of Medicine & CERVO Brain Research Center, Université Laval, Quebec City, QC G1J 2G3, Canada; Department of Biochemistry, Federal University of Santa Catarina, Florianopolis, Brazil.
² Department of Psychiatry and Neuroscience, Faculty of Medicine & CERVO Brain Research Center, Université Laval, Quebec City, QC G1J 2G3, Canada. Electronic address: caroline.menard@fmed.ulaval.ca.

PMID: 30408435
DOI: 10.1016/j.neuron.2018.10.039

Abstract

Increasing evidence supports a role for inflammation in the development of mood disorders. In this issue of Neuron, Leng et al. (2018) show that reduction of menin expression in astrocytes of stress-related brain regions exacerbates neuroinflammation, promoting the establishment of depression-like behaviors in mice.

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MeSH terms

Animals
Astrocytes*
Brain
Depression*
Inflammation
Mice
Neurons