Inflamed Astrocytes: A Path to Depression Led by Menin

Neuron. 2018 Nov 7;100(3):511-513. doi: 10.1016/j.neuron.2018.10.039.


Increasing evidence supports a role for inflammation in the development of mood disorders. In this issue of Neuron, Leng et al. (2018) show that reduction of menin expression in astrocytes of stress-related brain regions exacerbates neuroinflammation, promoting the establishment of depression-like behaviors in mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Astrocytes*
  • Brain
  • Depression*
  • Inflammation
  • Mice
  • Neurons