Prognostic Implications of Left Ventricular Hypertrophy

Prog Cardiovasc Dis. 2018 Nov-Dec;61(5-6):446-455. doi: 10.1016/j.pcad.2018.11.002. Epub 2018 Nov 6.


Left ventricular hypertrophy (LVH) was one of the earliest studied echocardiographic characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over recent years, this reliable and relevant variable can often be overlooked. In this paper, we discuss appropriate techniques for accurate analysis, underlying pathophysiology, and the contributions from various risk factors. The prognostic implications of LVH on stroke, serious arrhythmias, and sudden cardiac death are reviewed. Finally, we examine the effect of therapy to reduce LVH and the resultant clinical outcomes.

Keywords: Cardiovascular disease; Echocardiography; Hypertension; Left ventricle; Left ventricular geometry; Left ventricular hypertrophy; Left ventricular mass.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac / diagnostic imaging
  • Arrhythmias, Cardiac / etiology*
  • Arrhythmias, Cardiac / physiopathology
  • Arrhythmias, Cardiac / therapy
  • Death, Sudden, Cardiac / etiology*
  • Echocardiography
  • Humans
  • Hypertrophy, Left Ventricular / complications*
  • Hypertrophy, Left Ventricular / diagnostic imaging
  • Hypertrophy, Left Ventricular / physiopathology
  • Hypertrophy, Left Ventricular / therapy
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors
  • Stroke / diagnostic imaging
  • Stroke / etiology*
  • Stroke / physiopathology
  • Stroke / therapy
  • Ventricular Function, Left*
  • Ventricular Remodeling*