Advances in antitumor effects of NSAIDs

doi:10.2147/CMAR.S175212

Review

. 2018 Oct 15:10:4631-4640.

doi: 10.2147/CMAR.S175212. eCollection 2018.

Advances in antitumor effects of NSAIDs

Zhen Zhang^{1

2}, Fulin Chen^{1

2}, Lijun Shang^{1

2

3}

Affiliations

¹ Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi Province 710069, People's Republic of China, lijunshang@hotmail.com, chenfl@nwu.edu.cn.
² Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, Shaanxi Province 710069, People's Republic of China, lijunshang@hotmail.com, chenfl@nwu.edu.cn.
³ School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, UK, lijunshang@hotmail.com.

PMID: 30410398
PMCID: PMC6197827
DOI: 10.2147/CMAR.S175212

Free PMC article

Review

Advances in antitumor effects of NSAIDs

Zhen Zhang et al. Cancer Manag Res. 2018.

Free PMC article

. 2018 Oct 15:10:4631-4640.

doi: 10.2147/CMAR.S175212. eCollection 2018.

Authors

Zhen Zhang^{1

2}, Fulin Chen^{1

2}, Lijun Shang^{1

2

3}

Affiliations

¹ Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi Province 710069, People's Republic of China, lijunshang@hotmail.com, chenfl@nwu.edu.cn.
² Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, Shaanxi Province 710069, People's Republic of China, lijunshang@hotmail.com, chenfl@nwu.edu.cn.
³ School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, UK, lijunshang@hotmail.com.

PMID: 30410398
PMCID: PMC6197827
DOI: 10.2147/CMAR.S175212

Abstract

In recent years, the reports on using nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer prevention and treatment have been on the rise. In 2017, the US Preventive Services Working Group issued primary prevention guidelines on the use of NSAIDs, especially aspirin, for cardiovascular disease and colorectal cancer, and formally established the role and status of aspirin in cancer prevention. However, the mechanism of NSAIDs on preventing cancer is still not clear. In this paper, the progress of the application of NSAIDs, especially aspirin, in the prevention and treatment of tumors in recent years is summarized, and new ideas and directions for the follow-up study are also discussed.

Keywords: NSAIDs; aspirin; cancer; platelets.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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References

1. Derry S, Loke YK, Li Z. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. Chinese Edition of BMJ. 2001;04:186–190. - PMC - PubMed
1. Yujie G. Clinical application and safety evaluation of non-steroidal anti-inflammatory drugs. Pract Pharm Clin Remedies. 2009;02:122–124.
1. Kang SU, Lee BS, Lee SH, Baek SJ, Shin YS, Kim CH. Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression. J Nutr Biochem. 2013;24(6):986–999. - PubMed
1. Kawahara T, Ishiguro H, Hoshino K, et al. Analysis of NSAID-activated gene 1 expression in prostate cancer. Urol Int. 2010;84(2):198–202. - PubMed
1. Retsky M, Rogers R, Demicheli R, et al. NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup. Breast Cancer Res Treat. 2012;134(2):881–888. - PubMed

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[1] Derry S, Loke YK, Li Z. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. Chinese Edition of BMJ. 2001;04:186–190. - PMC - PubMed

[2] Derry S, Loke YK, Li Z. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. Chinese Edition of BMJ. 2001;04:186–190. - PMC - PubMed

[3] Yujie G. Clinical application and safety evaluation of non-steroidal anti-inflammatory drugs. Pract Pharm Clin Remedies. 2009;02:122–124.

[4] Yujie G. Clinical application and safety evaluation of non-steroidal anti-inflammatory drugs. Pract Pharm Clin Remedies. 2009;02:122–124.

[5] Kang SU, Lee BS, Lee SH, Baek SJ, Shin YS, Kim CH. Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression. J Nutr Biochem. 2013;24(6):986–999. - PubMed

[6] Kang SU, Lee BS, Lee SH, Baek SJ, Shin YS, Kim CH. Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression. J Nutr Biochem. 2013;24(6):986–999. - PubMed

[7] Kawahara T, Ishiguro H, Hoshino K, et al. Analysis of NSAID-activated gene 1 expression in prostate cancer. Urol Int. 2010;84(2):198–202. - PubMed

[8] Kawahara T, Ishiguro H, Hoshino K, et al. Analysis of NSAID-activated gene 1 expression in prostate cancer. Urol Int. 2010;84(2):198–202. - PubMed

[9] Retsky M, Rogers R, Demicheli R, et al. NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup. Breast Cancer Res Treat. 2012;134(2):881–888. - PubMed

[10] Retsky M, Rogers R, Demicheli R, et al. NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup. Breast Cancer Res Treat. 2012;134(2):881–888. - PubMed

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Advances in antitumor effects of NSAIDs

Affiliations

Advances in antitumor effects of NSAIDs

Authors

Affiliations

Abstract

Conflict of interest statement

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