The neurophysiologic investigation of small fiber neuropathies

Muscle Nerve. Jul-Aug 1987;10(6):537-45. doi: 10.1002/mus.880100608.


We have applied our technique for the measurement of thermal thresholds to 25 patients referred with symptoms and signs of small fiber peripheral neuropathy in whom conventional electrophysiological indices were individually within the range of normal values for our laboratory. Vibration threshold determinations were also within normal range. Significant abnormalities of thermal thresholds were noted in all patients. The results indicate that the technique provides an accurate, easily performed and reproducible index of function in small A delta and C groups of nerve fibers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Electromyography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neural Conduction
  • Neurologic Examination / methods*
  • Pain / diagnosis
  • Peripheral Nerves / physiopathology
  • Peripheral Nervous System Diseases / diagnosis*
  • Peripheral Nervous System Diseases / physiopathology
  • Sensory Thresholds
  • Thermosensing
  • Vibration