Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov 9;19(1):218.
doi: 10.1186/s12931-018-0921-x.

Therapeutic Potential of Products Derived From Mesenchymal Stem/Stromal Cells in Pulmonary Disease

Free PMC article

Therapeutic Potential of Products Derived From Mesenchymal Stem/Stromal Cells in Pulmonary Disease

Arezoo Mohammadipoor et al. Respir Res. .
Free PMC article


Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal characteristics and the ability to differentiate into tissue-specific cells. Their therapeutic potential appears promising as evident from their efficacy in several animal models of pulmonary disorders as well as early-phase clinical trials of acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). Such therapeutic efficacy might be attributed to MSC-derived products (the "secretome"), namely conditioned media (CM) and extracellular vesicles (EVs), which have been shown to play pivotal roles in the regenerative function of MSCs. Importantly, the EVs secreted by MSCs can transfer a variety of bioactive factors to modulate the function of recipient cells via various mechanisms, including ligand-receptor interactions, direct membrane fusion, endocytosis, or phagocytosis.Herein, we review the current state-of-the-science of MSC-derived CM and EVs as potential therapeutic agents in lung diseases. We suggest that the MSC-derived secretome might be an appropriate therapeutic agent for treating aggressive pulmonary disorders because of biological and logistical advantages over live cell therapy. Nonetheless, further studies are warranted to elucidate the safety and efficacy of these components in combating pulmonary diseases.

Keywords: Acute lung injury; Acute respiratory distress syndrome; Bronchopulmonary dysplasia; Chronic obstructive pulmonary disease; Conditioned media; Extracellular vesicles; Lung disease; Mesenchymal stem cells; Pulmonary fibrosis.

Conflict of interest statement

Ethics approval and consent to participate

Not Applicable.

Consent for publication

Not Applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Fig. 1
Fig. 1
Extracellular vesicles secreted by mesenchymal stem cells transfer their cargo to the recipient cells. In culture mesenchymal stem cells secrete exosomes and microvesicles that can transfer variety of bioactive factors to the recipient cells via ligand-receptor interaction, direct membrane fusion, endocytosis, or phagocytosis. Ang1—angiopoietin 1, CXCR7 – chemokine (C-X-C motif) receptor 7, EGFr – epidermal growth factor receptor, IL-8 – interleukin 8, IL-1ra – IL-1 receptor antagonist, KGF – keratinocyte growth factor, mRNA – messenger RNA, miRNA – micro RNA, PS – phosphatidylserine, TGF-β – transforming growth factor beta, VEGF – vascular endothelial growth factor

Similar articles

See all similar articles

Cited by 13 articles

See all "Cited by" articles


    1. Sueblinvong V, Weiss DJ. Stem cells and cell therapy approaches in lung biology and diseases. Transl Res. 2010;156(3):188–205. doi: 10.1016/j.trsl.2010.06.007. - DOI - PMC - PubMed
    1. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685–1693. doi: 10.1056/NEJMoa050333. - DOI - PubMed
    1. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012;122(8):2731–2740. doi: 10.1172/JCI60331. - DOI - PMC - PubMed
    1. Przybysz TM, Heffner AC. Early treatment of severe acute respiratory distress syndrome. Emerg Med Clin North Am. 2016;34(1):1–14. doi: 10.1016/j.emc.2015.08.001. - DOI - PubMed
    1. Batchinsky AI, Burkett SE, Zanders TB, Chung KK, Regn DD, Jordan BS, Necsoiu C, Nguyen R, Hanson MA, Morris MJ, et al. Comparison of airway pressure release ventilation to conventional mechanical ventilation in the early management of smoke inhalation injury in swine. Crit Care Med. 2011;39(10):2314–2321. doi: 10.1097/CCM.0b013e318225b5b3. - DOI - PubMed

MeSH terms