[Randomized double-blind study of the analgesic effect of caerulein and morphine in chronic tumor pain]

Onkologie. 1988 Apr;11(2):77-80. doi: 10.1159/000216492.
[Article in German]


Caerulein (CRL) (5 micrograms i.m.) and morphine (10 mg i.m.) have been tested for their analgesic activity in a double blind randomized study in a total of 36 patients with medium to severe tumor pains. A decrease of more than 20 mm on a visual analogue scale (VAS) was taken as a criterion for successful therapy. This was the case in 67% of the patients treated with morphine and 50% of those treated with CRL. This difference is statistically not significant, but CRL has significantly fewer side-effects than morphine. The present data do not permit a definitive judgement on the value of CRL in the treatment of tumor pains. Further studies with more patients and different doses and administration routes are warranted.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Ceruletide / administration & dosage*
  • Chronic Disease
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Middle Aged
  • Morphine / administration & dosage*
  • Neoplasms / physiopathology*
  • Pain / drug therapy*
  • Pain Measurement
  • Random Allocation


  • Morphine
  • Ceruletide