Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Apr;37(4):402-415.
doi: 10.1016/j.tibtech.2018.10.001. Epub 2018 Nov 6.

Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology


Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology

Dominic Laaf et al. Trends Biotechnol. .


Cellular communication events are mediated by interactions between cell-surface sugars and lectins, which are carbohydrate-binding proteins. Galectins are β-galactosyl-binding lectins that bridge molecules by their sugar moieties, forming a signaling and adhesion network. Severe changes in glycosylation and galectin expression accompany major processes in oncogenesis, cardiovascular disorders, and other pathologies, making galectins attractive therapeutic targets. Here we discuss advanced strategies of chemo-enzymatic carbohydrate synthesis for creating lead glycomimetics and (neo-)glycoconjugates for galectin-1 and -3 targeting in biomedicine and biotechnology. We will describe the challenges and bottlenecks on the route into biomedical and biotechnological practice and present the first clinical candidates. The coming era will see an exciting translation of selective well-defined high-affinity galectin ligands from bench to bedside.

Keywords: Cancer; galectin; glycoconjugate; glycomimetic; neo-glycoprotein; thiodigalactoside.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

MeSH terms

LinkOut - more resources