Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis

Justin T Schwartz; David W Morris; Margaret H Collins; Marc E Rothenberg; Patricia C Fulkerson

doi:10.1016/j.jaci.2018.10.036

Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis

J Allergy Clin Immunol. 2019 Mar;143(3):1221-1224.e3. doi: 10.1016/j.jaci.2018.10.036. Epub 2018 Nov 9.

Authors

Justin T Schwartz¹, David W Morris¹, Margaret H Collins², Marc E Rothenberg¹, Patricia C Fulkerson³

Affiliations

¹ Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
² Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³ Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: Patricia.Fulkerson@cchmc.org.

Abstract

Blood eosinophil progenitors (EoPs) correlate with tissue pathology during active eosinophilic esophagitis (EoE), providing additional evidence for blood EoP levels as a biomarker for disease activity and suggesting a role for EoPs in EoE pathogenesis.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Eosinophilic Esophagitis / blood*
Eosinophilic Esophagitis / immunology
Eosinophilic Esophagitis / pathology*
Eosinophils*
Esophagus / pathology*
Female
Humans
Leukocyte Count
Male
Severity of Illness Index

Abstract

Publication types

MeSH terms

Grants and funding