The Differences Between Intracranial Mesenchymal Chondrosarcoma and Conventional Chondrosarcoma in Clinical Features and Outcomes

World Neurosurg. 2019 Feb:122:e1078-e1082. doi: 10.1016/j.wneu.2018.10.230. Epub 2018 Nov 9.

Abstract

Objective: To report differences in clinical features and outcomes between intracranial mesenchymal chondrosarcoma (MCS) and conventional chondrosarcoma (CCS).

Methods: Clinical data of patients with primary intracranial MCS and CCS were retrospectively extracted and analyzed to compare differences between MCS and CCS.

Results: Seventy-four patients with intracranial chondrosarcoma (61 cases with MCS and 13 cases with CCS) were included. Compared with patients with CCS, patients with MCS presented at a younger mean age (21.1 years vs. 34.5 years, P < 0.001) and had a poor mean preoperative Karnofsky performance scale score (64.6 vs. 77.8, P = 0.014). Compared with CCS, MCS was less often located in the skull base (38.5% vs. 96.7%, P < 0.001) and had a larger tumor volume (87.8 cm3 vs. 26.7 cm3, P < 0.001). Rates of gross total resection in MCS and CCS subgroups were 41.1% (n = 25) and 46.2% (n = 6), respectively; rates of adjuvant radiotherapy postoperatively were 44.2% (n = 27) and 46.2% (n = 6), respectively. After mean follow-up of 41.7 months, 1-year, 3-year, and 5-year overall survival and progression-free survival of MCS were significantly shorter than overall survival and progression-free survival of CCS. Multivariate analysis revealed that tumor pathology and extent of surgery were independent predictors for tumor recurrence.

Conclusions: Clinical features of MCS are quite different from CCS. Treatment strategies used for CCS do not yield satisfactory outcomes for MCS. Treatment of MCS should be aggressive and individualized.

Keywords: Clinical characteristics; Conventional chondrosarcoma; Mesenchymal chondrosarcoma; Prognosis.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / mortality
  • Bone Neoplasms / surgery*
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / mortality
  • Brain Neoplasms / surgery*
  • Chondrosarcoma / diagnostic imaging
  • Chondrosarcoma / mortality
  • Chondrosarcoma / surgery
  • Chondrosarcoma, Mesenchymal / diagnostic imaging*
  • Chondrosarcoma, Mesenchymal / mortality
  • Chondrosarcoma, Mesenchymal / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Survival Rate / trends
  • Treatment Outcome
  • Young Adult