Microbial treatment: the potential application for Parkinson's disease

Neurol Sci. 2019 Jan;40(1):51-58. doi: 10.1007/s10072-018-3641-6. Epub 2018 Nov 10.


Alterations in the composition of the intestinal flora are associated with the pathophysiology of Parkinson's disease (PD). More importantly, the possible cause-effect links between gut flora and PD pathogenesis have been identified using PD animal models. Recent studies have found that probiotics improve the symptoms associated with constipation in PD patients. In addition, fecal microbiota transplantation (FMT) was recently shown to provide a protective effect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice. Effective microbial therapy for PD includes probiotics and FMT. Therefore, microbial therapy may be a useful and novel approach for treatment of PD. In this review, I discuss the use of microbial treatment in PD.

Keywords: Fecal microbiota transplantation; Intestinal flora; MPTP; Parkinson’s disease; Probiotic treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Fecal Microbiota Transplantation / methods*
  • Gastrointestinal Microbiome / drug effects*
  • Gastrointestinal Microbiome / physiology
  • Humans
  • Parkinson Disease / microbiology
  • Parkinson Disease / therapy*
  • Probiotics / administration & dosage*
  • Treatment Outcome