Serotonin in retina

Biochimie. 2019 Jun;161:51-55. doi: 10.1016/j.biochi.2018.11.006. Epub 2018 Nov 9.


The expression of serotonin (5-HT) in the retina was first reported in the sixties. The detection of vesicular monoamine transporter and serotonin receptors in several retinal cells confirm that 5-HT is playing a neuromodulatory role in this structure. Whereas signaling pathways activated by 5-HT receptor binding has been poorly investigated so far, numerous data demonstrated that 5-HT is involved in retinal physiology, retinal physiopathology and photoreceptor survival.

Keywords: Receptor; Retina; Serotonin.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Receptors, Serotonin / metabolism*
  • Retina / metabolism
  • Retina / physiopathology*
  • Serotonin / metabolism*


  • Receptors, Serotonin
  • Serotonin