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Meta-Analysis
. 2018 Nov 12;18(1):440.
doi: 10.1186/s12884-018-2068-7.

The Effect of Exercise During Pregnancy on Gestational Diabetes Mellitus in Normal-Weight Women: A Systematic Review and Meta-Analysis

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Free PMC article
Meta-Analysis

The Effect of Exercise During Pregnancy on Gestational Diabetes Mellitus in Normal-Weight Women: A Systematic Review and Meta-Analysis

Wai-Kit Ming et al. BMC Pregnancy Childbirth. .
Free PMC article

Abstract

Background: Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, and it has both short- and long-term adverse effects on the health of mothers and fetuses. To investigate the effect of exercise during pregnancy on the occurrence of GDM among normal-weight pregnant women.

Methods: We searched for studies published between January 1994 and June 2017 that appeared in the Web of Science, Scopus, ClinicalTrials.gov or Cochrane library databases. Randomized controlled trials that investigated the preventive effect of exercise on GDM in normal-weight women were included. Interventions including any confounding factors (e.g., dietary) were excluded. We extracted maternal characteristics, the diagnostic criteria of GDM, and basic information for intervention and obstetric outcomes. The primary outcome was the occurrence of GDM, and the secondary outcomes included gestational weight gain, gestational age at birth, birth weight, and the odds of cesarean section. A meta-analysis was conducted based on calculations of pooled estimates using the random-effects model.

Results: Eight studies were included in this systematic review and meta-analysis. Exercise during pregnancy was shown to decrease the occurrence of GDM [RR = 0.58, 95% CI (0.37, 0.90), P = 0.01 and RR = 0.60, 95% CI (0.36, 0.98), P = 0.04 based on different diagnosis criteria, respectively] in normal-weight women. Regarding secondary outcomes, exercise during pregnancy can decrease gestational weight gain [MD = - 1.61, 95% CI (- 1.99, - 1.22), P<0.01], and had no significant effects on gestational age at birth [MD = - 0.55, 95% CI (- 1.57, 0.47), P = 0.29], birth weight [MD = - 18.70, 95% CI (- 52.49, 15.08), P = 0.28], and the odds of caesarean section [RR = 0.88, 95% CI (0.72, 1.08), P = 0.21], respectively.

Conclusions: Exercise during pregnancy can ostensibly decrease the occurrence of GDM without reducing gestational age at delivery and increasing the odds of cesarean section in normal-weight women.

Keywords: Exercise; Gestational diabetes mellitus; Meta-analysis; Systematic review.

Conflict of interest statement

Competing interest

The authors declare that they have no competing interests.

Ethics approval and consent to participate

Not applicable.

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Not applicable.

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Figures

Fig. 1
Fig. 1
Flow diagram of studies selection
Fig. 2
Fig. 2
Funnel plot for assessing publication bias SE: standard error; RR: relative risk
Fig. 3
Fig. 3
Assessment of risk of bias. (a) Risk of bias graph about each risk of bias item presented as percentage across all included studies. (b) Summary of risk for bias for each trial; Plus sign: low risk of bias; minus sign: high risk of bias; question mark: unclear risk of bias
Fig. 4
Fig. 4
Forest plot for the meta-analysis of the occurrence of gestational diabetes mellitus (1)
Fig. 5
Fig. 5
Forest plot for the meta-analysis of the occurrence of gestational diabetes mellitus (2)

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