Mechanisms of reduced sleepiness symptoms in heart failure and obstructive sleep apnea

J Sleep Res. 2019 Oct;28(5):e12778. doi: 10.1111/jsr.12778. Epub 2018 Nov 13.

Abstract

Patients with both heart failure and obstructive sleep apnea often have poor, repeatedly disrupted sleep, and yet they frequently do not complain of excessive daytime sleepiness. Understanding this lack of perceived sleepiness is crucial for the case identification and treatment of obstructive sleep apnea in the heart failure population at high risk of this disease, especially given the association between untreated obstructive sleep apnea and mortality among patients with heart failure. In this review, we present epidemiologic evidence concerning the lack of sleepiness symptoms in heart failure and obstructive sleep apnea, explore possible mechanistic explanations for this relationship, assess the benefits of treatment in this population, discuss implications for clinical practice and explore directions for future research.

Keywords: adults; cardiovascular disease; daytime sleepiness.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Female
  • Heart Failure / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Sleep Apnea, Obstructive / physiopathology*
  • Wakefulness / physiology*