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Review
. 2019 Mar;597(5):1299-1309.
doi: 10.1113/JP277071. Epub 2018 Dec 17.

The relationships and interactions between age, exercise and physiological function

Norman R Lazarus  1 , Janet M Lord  2   3 , Stephen D R Harridge  1
Affiliations
Review

The relationships and interactions between age, exercise and physiological function

Norman R Lazarus et al. J Physiol. 2019 Mar.

Abstract

This brief review focuses on the relationships and interactions between human ageing, exercise and physiological function. It explores the importance of the selection of participants for ageing research, the strengths and deficiencies of both cross-sectional and longitudinal studies, and the complexities involved in understanding time-dependent, lifelong physiological processes. As being physically active is crucial to fostering healthy ageing, it is essential that participants in health and ageing research are defined in terms of their physical activity/exercise status as well as other lifestyle factors. Comparisons of exercisers with non-exercisers has suggested that there is a mosaic of regulation of ageing both within and across physiological systems. We suggest that four broad categories exist which encompass this regulation. These are (i) systems and indices that are age dependent, but activity independent; (ii) systems that are age dependent, but also malleable by exercise; (iii) systems that are not age affected but are altered by exercise; and (iv) systems that are neither age nor activity dependent. We briefly explore the concept of a mosaic of regulation in a selection of physiological systems. These include skeletal muscle, the immune and endocrine systems, gastrointestinal as well as cognitive function. We go onto examine how these categories might fit within the broad framework of understanding the physiology of human ageing.

Keywords: Ageing; Exercise; Human physiology.

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Figures

Figure 1
Figure 1
A schematic overview of the hypothesised regulation of healthy or diseased older phenotypes through the interaction of ageing an exercise
See this image and copyright information in PMC

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References

    1. ACSM (2013). ACSM's Guidelines for Exercise Testing and Prescription, 9th edn. American College of Sports Medicine/Lippincott Williams & Wilkins, Baltimore, Philadelphia.
    1. Arbab‐Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thomas JD, Palmer D & Levine BD (2004). Effect of aging and physical activity on left ventricular compliance. Circulation 110, 1799–805. - PubMed
    1. Atherton PJ, Etheridge T, Watt P, Wilkinson D, Rankin D, Smith K & Rennie MJ (2011). The muscle‐full anabolic set‐point in response to oral protein is lower in muscle of older men than in young men. J Physiol 590, 1049–1057.
    1. Baker AB & Tang YQ (2010). Aging performance for masters records in athletics, swimming, rowing, cycling, triathlon, and weightlifting. Exp Aging Res 36, 453–477. - PubMed
    1. Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel JP, Lloyd‐Sherlock P, Epping‐Jordan JE, Peeters GMEEG, Mahanani WR, Thiyagarajan JA & Chatterji S (2016). The World report on ageing and health: A policy framework for healthy ageing. Lancet 387, 2145–2154. - PMC - PubMed

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