Metabolic Flexibility in Leukemia-Adapt or Die

Boaz Nachmias; Aaron D Schimmer

doi:10.1016/j.ccell.2018.10.012

Metabolic Flexibility in Leukemia-Adapt or Die

Cancer Cell. 2018 Nov 12;34(5):695-696. doi: 10.1016/j.ccell.2018.10.012.

Authors

Boaz Nachmias¹, Aaron D Schimmer²

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
² Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address: aaron.schimmer@utoronto.ca.

PMID: 30423291
DOI: 10.1016/j.ccell.2018.10.012

Abstract

In this issue of Cancer Cell, Jones et al. demonstrate that LSCs are metabolically inflexible. LSCs rely on amino acid metabolism to fuel oxidative phosphorylation and cannot compensate with other fuel sources following amino acid depletion. Combined venetoclax and azacitidine reduces amino acid uptake, partly explaining the anti-LSC effects.

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MeSH terms

Amino Acids
Humans
Leukemia, Myeloid, Acute*
Neoplastic Stem Cells*
Oxidative Phosphorylation

Substances

Amino Acids