Role of amino acid metabolism in angiogenesis

Vascul Pharmacol. 2019 Jan;112:17-23. doi: 10.1016/j.vph.2018.11.001. Epub 2018 Nov 10.


The role of endothelial metabolism represents a crucial element governing the formation and the differentiation of blood vessels, termed angiogenesis. Besides glycolysis and fatty acid oxidation, endothelial cells rely on specific amino acids to proliferate, migrate, and survive. In this review we focus on the metabolism of those amino acids and the intermediates that hold an established function within angiogenesis and endothelial pathophysiology. We also discuss recent work which provides a rationale for specific amino acid-restricted diets and its beneficial effects on vascular tissues, including extending the life span and preventing the development of a variety of diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / metabolism*
  • Animals
  • Diet, Protein-Restricted
  • Endothelial Cells / metabolism*
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Humans
  • Neovascularization, Physiologic*
  • Signal Transduction
  • Vascular Diseases / diet therapy
  • Vascular Diseases / metabolism
  • Vascular Diseases / physiopathology


  • Amino Acids