Spices and Atherosclerosis

Nutrients. 2018 Nov 10;10(11):1724. doi: 10.3390/nu10111724.


Cardiovascular disease is one of the leading causes of death and disability in the world. Atherosclerosis, characterized by lipid accumulation and chronic inflammation in the vessel wall, is the main feature of cardiovascular disease. Although the amounts of fruits and vegetables present in the diets vary by country, diets, worldwide, contain large amounts of spices; this may have positive or negative effects on the initiation and development of atherosclerosis. In this review, we focused on the potential protective effects of specific nutrients from spices, such as pepper, ginger, garlic, onion, cinnamon and chili, in atherosclerosis and atherosclerotic cardiovascular disease. The mechanisms, epidemiological analysis, and clinical studies focusing on a variety of spices are covered in this review. Based on the integrated information, we aimed to raise specific recommendations for people with different dietary styles for the prevention of atherosclerotic cardiovascular disease through dietary habit adjustments.

Keywords: atherosclerosis; atherosclerotic cardiovascular disease; nutrients; spices.

Publication types

  • Review

MeSH terms

  • Atherosclerosis / prevention & control*
  • Diet*
  • Feeding Behavior*
  • Humans
  • Magnoliopsida*
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Spices*


  • Plant Extracts