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Review
, 2018, 1535194
eCollection

The Biology and Role of Interleukin-32 in Tuberculosis

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Review

The Biology and Role of Interleukin-32 in Tuberculosis

Wu Li et al. J Immunol Res.

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality globally, with nearly 10.4 million new cases of incidence and over 1.7 million deaths annually. Drug-resistant M. tuberculosis strains, especially multidrug-resistant or extensively drug-resistant strains, have further intensified the problem associated with tuberculosis control. Host-directed therapy is a promising alternative for tuberculosis control. IL-32 is increasingly recognized as an important host molecule against tuberculosis. In this review, we highlight the proinflammatory properties of IL-32 and the mode of action of IL-32 in mycobacterial infections to inspire the development of novel immunity-based countermeasures and host-directed therapies against tuberculosis.

Figures

Figure 1
Figure 1
Endogenous IL-32-induced signaling pathway activation in macrophages and the potential roles of this pathway in M. tuberculosis infection.

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