Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products-A market survey

Contact Dermatitis. 2019 Feb;80(2):110-113. doi: 10.1111/cod.13151. Epub 2018 Nov 13.

Abstract

Background: There was a global epidemic of methylchloroisothiazolinone (MCI) and/or methylisothiazolinone (MI) contact allergy from 2009 to 2015. In response, the Thai Ministry of Public Health regulated the use of MCI/MI in cosmetics.

Objective: To survey the presence of MCI/MI and MI alone, as labelled on cosmetics sold on the Thai market, before and after the ministerial directive.

Methods: The presence of MCI and/or MI in leave-on and rinse-off cosmetics sold on the market, based on the labelling of ingredients in 3445 products, was analysed.

Results: Before the implementation date, most leave-on products contained MCI/MI. After the regulations came into force, the only leave-on cosmetic subcategories that complied with the law were facial skin-care, sunscreen and make-up products. MCI/MI and MI alone were found on the labels of both leave-on and rinse-off products, the presence of each varying between product subcategories.

Conclusions: Despite the ministerial regulations restricting their use, MCI and/or MI are still found in cosmetics sold on the Thai market. Dermatologists should be aware of this situation, and counsel patients to avoid products containing MCI and/or MI.

Keywords: cosmetics; ingredient labelling; isothiazolinones; methylchloroisothiazolinone; methylisothiazolinone; skin-care products.

MeSH terms

  • Anti-Infective Agents / adverse effects*
  • Cosmetics / chemistry*
  • Dermatitis, Allergic Contact / etiology*
  • Humans
  • Legislation as Topic
  • Product Labeling
  • Retrospective Studies
  • Thailand
  • Thiazoles / adverse effects*

Substances

  • Anti-Infective Agents
  • Cosmetics
  • Thiazoles
  • 2-methyl-4-isothiazolin-3-one
  • 5-chloro-2-methyl-4-isothiazolin-3-one