Psychiatric side effects during the treatment of Parkinson's disease

J Neural Transm Suppl. 1988;27:117-22. doi: 10.1007/978-3-7091-8954-2_11.


Dopaminergic agents including both levodopa and direct-acting agonists induce a variety psychiatric side-effects of which psychosis is the most significant. When this occurs early in the course of treatment, there is usually a history of prior psychotic illness. Chronic treatment can, however, elicit psychosis in individuals without such a history. The possible pathogenesis of this is reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dreams
  • Dyskinesia, Drug-Induced / drug therapy
  • Hallucinations / chemically induced
  • Humans
  • Levodopa / adverse effects*
  • Mental Disorders / chemically induced*
  • Mental Disorders / psychology
  • Paranoid Disorders / chemically induced
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / physiopathology
  • Serotonin / physiology
  • Severity of Illness Index
  • Sleep Wake Disorders / chemically induced


  • Serotonin
  • Levodopa