POPs' effect on cardiometabolic and inflammatory profile in a sample of women with obesity and hypertension

Arch Environ Occup Health. 2019;74(6):310-321. doi: 10.1080/19338244.2018.1535480. Epub 2018 Nov 15.


Persistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) were collected. Median concentrations of ∑HCH and ∑POPs in vAT were significantly higher in treated women. VAT ∑HCH and scAT ∑HCH and ∑POPs concentrations were positively correlated with systolic blood pressure in the non-treated group. Our findings suggest that exposure to POPs and its accumulation in vAT and circulating in plasma may be associated to a higher cardiovascular risk in women with obesity and hypertension, with or without antihypertensive treatment.

Keywords: Cardiometabolic risk; hypertension; inflammation; obesity; persistent organic pollutants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects*
  • Adipose Tissue / metabolism
  • Adult
  • Air Pollutants / adverse effects
  • Air Pollutants / blood
  • Environmental Exposure / adverse effects
  • Female
  • Humans
  • Hypertension / chemically induced*
  • Hypertension / epidemiology
  • Metabolic Syndrome
  • Middle Aged
  • Obesity / chemically induced*
  • Obesity / epidemiology
  • Organic Chemicals / blood*
  • Organic Chemicals / metabolism*
  • Risk Assessment
  • Young Adult


  • Air Pollutants
  • Organic Chemicals