Motor performance in hyperactive children treated with imipramine

Percept Mot Skills. 1988 Jun;66(3):763-9. doi: 10.2466/pms.1988.66.3.763.


The effects of the tricyclic antidepressant imipramine were evaluated in a study of 9 children with Attention Deficit-Hyperactivity Disorder. The study was double-blind, placebo-controlled, with three drug conditions, low, medium, and high doses. The focus was on neuropsychological drug effects. Imipramine exerted negative dose-response effects on motor performance (motor speed, motor pursuit), while it improved hyperactive behavior and attention and raised the heart rate slightly.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Arousal / drug effects
  • Attention / drug effects
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Child
  • Clinical Trials as Topic
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Imipramine / adverse effects
  • Imipramine / therapeutic use*
  • Male
  • Motor Activity / drug effects*
  • Psychomotor Performance / drug effects*
  • Random Allocation


  • Imipramine