A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain

Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:3362-3365. doi: 10.1109/EMBC.2018.8512993.

Abstract

Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Brain*
  • Electrophysiological Phenomena
  • Neurons
  • Primates