3D Printed Cranial Window System for Chronic μECoG Recording

Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:4591-4594. doi: 10.1109/EMBC.2018.8513117.

Abstract

Chronic studies of flexible μECoG electrodes and the electrode-brain interface have been limited by the inability to assess tissue response over time. The electrophysiological system presented here combines epidural microelectrocorticographic (μECoG) recording capabilities with the ability to visualize tissue response over time through light microscopy and optical coherence tomography (OCT). With the ability to interchange both the electrode and the electronics, and a flushing port for injection of flushing saline and/or drugs, this 3D printed system has future applications in chronic electrophysiology, optogenetics, and advanced imaging methods.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Brain / diagnostic imaging*
  • Electrocorticography / instrumentation*
  • Electrodes, Implanted*
  • Electrophysiological Phenomena
  • Female
  • Optogenetics
  • Printing, Three-Dimensional*
  • Rats, Sprague-Dawley
  • Tomography, Optical Coherence