Continuous Phase Estimation for Phase-Locked Neural Stimulation Using an Autoregressive Model for Signal Prediction

Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul:2018:4736-4739. doi: 10.1109/EMBC.2018.8513232.

Abstract

Neural oscillations enable communication between brain regions. Closed-loop brain stimulation attempts to modify this activity by stimulation locked to the phase of concurrent neural oscillations. If successful, this may be a major step forward for clinical brain stimulation therapies. The challenge for effective phase-locked systems is accurately calculating the phase of a source oscillation in real time. The basic operations of filtering the source signal to a frequency band of interest and extracting its phase cannot be performed in real time without distortion. We present a method for continuously estimating phase that reduces this distortion by using an autoregressive model to predict the future of a filtered signal before passing it though the Hilbert transform. This method outperforms published approaches on real data and is available as a reusable open-source module. We also examine the challenge of compensating for the filter phase response and outline promising directions of future study.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Models, Neurological
  • Neurons*