Wrapping up the fats-a structure of the lipid droplet biogenesis protein seipin

Maria Bohnert

doi:10.1083/jcb.201811021

Wrapping up the fats-a structure of the lipid droplet biogenesis protein seipin

J Cell Biol. 2018 Dec 3;217(12):4053-4054. doi: 10.1083/jcb.201811021. Epub 2018 Nov 15.

Author

Maria Bohnert^{1

2}

Affiliations

¹ Institute of Cell Dynamics and Imaging, University of Münster, Münster, Germany bohnertm@uni-muenster.de.
² Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, Münster, Germany.

Abstract

The lipid droplet (LD) biogenesis protein seipin is crucial for formation of normal LDs, but its exact functional role has been enigmatic. In this issue, Sui et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201809067) report the cryo--electron microscopy structure of seipin, which provides novel insights into how seipin might mediate LD formation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cryoelectron Microscopy
GTP-Binding Protein gamma Subunits*
Lipid Droplets
Membrane Proteins
Saccharomyces cerevisiae Proteins*

Substances

GTP-Binding Protein gamma Subunits
Membrane Proteins
Saccharomyces cerevisiae Proteins