The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review

doi:10.1007/s11060-018-03004-y

. 2019 Feb;141(3):567-573.

doi: 10.1007/s11060-018-03004-y. Epub 2018 Nov 15.

The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review

Chenran Zhang^{1

2

3

4}, Frederick A Boop^{5

6

7

8}, John Ruge⁹

Affiliations

¹ Department of Pediatric Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665 Kongjiang RD, Shanghai, 200092, China. christopher205121@hotmail.com.
² Clinical Research Unit, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. christopher205121@hotmail.com.
³ Department of Neurosurgery, Le Bonheur Children's Hospital, Memphis, TN, USA. christopher205121@hotmail.com.
⁴ St Jude Children's Research Hospital, Memphis, TN, USA. christopher205121@hotmail.com.
⁵ Department of Neurosurgery, Le Bonheur Children's Hospital, Memphis, TN, USA.
⁶ St Jude Children's Research Hospital, Memphis, TN, USA.
⁷ Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN, USA.
⁸ Semmes-Murphey Brain and Spine Institute, Memphis, TN, USA.
⁹ Department of Pediatric Neurosurgery, Advocate Children's Hospital, Park Ridge, IL, USA.

PMID: 30443833
DOI: 10.1007/s11060-018-03004-y

The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review

Chenran Zhang et al. J Neurooncol. 2019 Feb.

. 2019 Feb;141(3):567-573.

doi: 10.1007/s11060-018-03004-y. Epub 2018 Nov 15.

Authors

Chenran Zhang^{1

2

3

4}, Frederick A Boop^{5

6

7

8}, John Ruge⁹

Affiliations

¹ Department of Pediatric Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665 Kongjiang RD, Shanghai, 200092, China. christopher205121@hotmail.com.
² Clinical Research Unit, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. christopher205121@hotmail.com.
³ Department of Neurosurgery, Le Bonheur Children's Hospital, Memphis, TN, USA. christopher205121@hotmail.com.
⁴ St Jude Children's Research Hospital, Memphis, TN, USA. christopher205121@hotmail.com.
⁵ Department of Neurosurgery, Le Bonheur Children's Hospital, Memphis, TN, USA.
⁶ St Jude Children's Research Hospital, Memphis, TN, USA.
⁷ Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN, USA.
⁸ Semmes-Murphey Brain and Spine Institute, Memphis, TN, USA.
⁹ Department of Pediatric Neurosurgery, Advocate Children's Hospital, Park Ridge, IL, USA.

PMID: 30443833
DOI: 10.1007/s11060-018-03004-y

Abstract

The compound, 5-aminolevulinic acid (5-ALA) is approved for fluorescence-guided resections of malignant gliomas in Europe and other countries for use in adults, but not for children. The application of 5-ALA in children remains an off-label use. Several case reports on fluorescence-guided surgery use in children have been published, yet no prospective study has been conducted. Here we systematically review the reported studies and discuss the usefulness, application, and safety of 5-ALA use in resection of pediatric brain tumors.

Keywords: 5-Aminolevulinic acid (5-ALA); Extent of resection; Pediatric brain tumor.

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[1] Lancet Oncol. 2006 May;7(5):392-401 - PubMed

[2] Lancet Oncol. 2006 May;7(5):392-401 - PubMed

[3] Anticancer Res. 2006 Sep-Oct;26(5B):3773-9 - PubMed

[4] Anticancer Res. 2006 Sep-Oct;26(5B):3773-9 - PubMed

[5] J Neurooncol. 2008 Mar;87(1):103-9 - PubMed

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[7] Childs Nerv Syst. 2009 Oct;25(10):1229-40 - PubMed

[8] Childs Nerv Syst. 2009 Oct;25(10):1229-40 - PubMed

[9] J Neurosurg Pediatr. 2009 Nov;4(5):484-6 - PubMed

[10] J Neurosurg Pediatr. 2009 Nov;4(5):484-6 - PubMed

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The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review

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The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review

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