Electrode fabrication and interface optimization for imaging of evoked peripheral nervous system activity with electrical impedance tomography (EIT)

J Neural Eng. 2019 Feb;16(1):016001. doi: 10.1088/1741-2552/aae868. Epub 2018 Nov 16.


Objective: Non-invasive imaging techniques are undoubtedly the ideal methods for continuous monitoring of neural activity. One such method, fast neural electrical impedance tomography (EIT) has been developed over the past decade in order to image neural action potentials with non-penetrating electrode arrays.

Approach: The goal of this study is two-fold. First, we present a detailed fabrication method for silicone-based multiple electrode arrays which can be used for epicortical or neural cuff applications. Secondly, we optimize electrode material coatings in order to achieve the best accuracy in EIT reconstructions.

Main results: The testing of nanostructured electrode interface materials consisting of platinum, iridium oxide, and PEDOT:pTS in saline tank experiments demonstrated that the PEDOT:pTS coating used in this study leads to more accurate reconstruction dimensions along with reduced phase separation between recording channels. The PEDOT:pTS electrodes were then used in vivo to successfully image and localize the evoked activity of the recurrent laryngeal fascicle from within the cervical vagus nerve.

Significance: These results alongside the simple fabrication method presented here position EIT as an effective method to image neural activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electric Impedance*
  • Equipment Design / methods*
  • Female
  • Laryngeal Nerves / diagnostic imaging*
  • Laryngeal Nerves / physiology*
  • Microelectrodes* / standards
  • Peripheral Nervous System / diagnostic imaging
  • Peripheral Nervous System / physiology
  • Sheep
  • Silicones
  • Tomography / methods*
  • Tomography / standards


  • Silicones