A double blind randomised placebo controlled trial of hexopal in primary Raynaud's disease

Clin Rheumatol. 1988 Mar;7(1):46-9. doi: 10.1007/BF02284056.


The peripheral vasospastic symptoms associated with Raynaud's disease continue to be an unsolved clinical problem. Hexopal (Hexanicotinate inositol) has shown promise in uncontrolled studies and its use in patients with Raynaud's disease may reduce such vasospasm. This study examines the effects of 4 g/day of Hexopal or placebo, during cold weather, in 23 patients with primary Raynaud's disease. The Hexopal group felt subjectively better and had demonstrably shorter and fewer attacks of vasospasm during the trial period. Serum biochemistry and rheology was not significantly different between the two groups. Although the mechanism of action remains unclear Hexopal is safe and is effective in reducing the vasospasm of primary Raynaud's disease during the winter months.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic
  • Cold Temperature
  • Double-Blind Method
  • Female
  • Fingers / blood supply
  • Humans
  • Male
  • Nicotinic Acids / therapeutic use*
  • Random Allocation
  • Raynaud Disease / blood
  • Raynaud Disease / drug therapy*
  • Raynaud Disease / physiopathology
  • Regional Blood Flow / drug effects
  • Time Factors


  • Nicotinic Acids
  • Inositol Niacinate