Bone Changes in Alcoholic Liver Cirrhosis. A Histomorphometrical Analysis of 52 Cases

Dig Dis Sci. 1988 Sep;33(9):1089-95. doi: 10.1007/BF01535783.

Abstract

Bone biopsies of 52 histologically confirmed alcoholic cirrhotic patients and 15 age- and sex-matched controls have been histomorphometrically analyzed determining trabecular bone volume (TBV), mineralized bone volume (MBV), and osteoid volume (OV). We also determined serum PTH, 25-OH-D3, calcitonin, FSH, LH, estradiol, testosterone, T3 and T4, urine cortisol, routine liver function tests, serum and urinary calcium, phosphorus, and magnesium. We found a high prevalence of osteoporosis: TBV was significantly lower in cirrhotic patients (T = 7.23, P less than 0.001), 41 of them being in the range of osteoporosis; none of them had osteomalacia. Levels of all the above-mentioned hormones and electrolytes were almost normal, and no correlation was found between them and liver function tests, as occurred with the bone parameters.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Bone and Bones / metabolism
  • Bone and Bones / pathology*
  • Calcium / blood
  • Calcium / urine
  • Female
  • Hormones / blood
  • Humans
  • Liver / pathology
  • Liver Cirrhosis, Alcoholic / metabolism
  • Liver Cirrhosis, Alcoholic / pathology*
  • Magnesium / blood
  • Magnesium / urine
  • Male
  • Middle Aged
  • Phosphorus / blood
  • Phosphorus / urine

Substances

  • Hormones
  • Phosphorus
  • Magnesium
  • Calcium