Comorbidity of Borderline Personality Disorder: Current Status and Future Directions

Psychiatr Clin North Am. 2018 Dec;41(4):583-593. doi: 10.1016/j.psc.2018.07.009. Epub 2018 Oct 16.


Patients with borderline personality disorder have high rates of comorbid mood, anxiety, substance use, and eating disorders. The longitudinal studies conducted on borderline patients over 10 years of prospective follow-up suggest that patients with borderline personality disorder experienced declining rates of Axis I disorders over time, but the rates of these disorders remained high compared with those with other personality disorders. In addition, patients whose borderline personality disorder remitted over time experienced a substantial decline in all comorbid Axis I disorders, but those whose borderline personality disorder did not remit over time, reported stable rates of comorbid disorders.

Keywords: Axis I disorders; BPD; Comorbidity; New onset; Prevalence; Recurrence; Remission.

Publication types

  • Review

MeSH terms

  • Anxiety Disorders / epidemiology*
  • Borderline Personality Disorder / diagnosis
  • Borderline Personality Disorder / epidemiology*
  • Comorbidity*
  • Humans
  • Mood Disorders / diagnosis
  • Mood Disorders / epidemiology*
  • Prospective Studies
  • Substance-Related Disorders / epidemiology