Crosstalk in cancer resistance and metastasis

Crit Rev Oncol Hematol. 2018 Dec:132:145-153. doi: 10.1016/j.critrevonc.2018.09.017. Epub 2018 Oct 4.


The main obstacles that lead to clinical failure in cancer treatment are the development of resistant to chemotherapy and a rise in invasive characteristics in cancer tumor cells due to prolonged chemotherapeutic processes. Recent studies have revealed some evidence about the existence of a direct relationship between development of drug resistance and triggering of invasive capability in tumor cells. Therefore, devising and application of chemotherapeutic procedures that are not prone to the development of chemotherapy resistance are necessary. Here, we focus on CD147, CD44, ANAX2, P-gp, MMPs, and UCH-L1 proteins involved in the crosstalk between metastasis and cancer treatment. We think that further structural and functional analysis of these proteins may direct scientists towards designing highly effective chemotherapy procedures.

Keywords: Cancer; Chemotherapy; Metastasis; Resistance.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Biomarkers, Tumor / genetics*
  • Drug Resistance, Neoplasm / genetics*
  • Humans
  • Neoplasm Metastasis
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Signal Transduction / drug effects*


  • Antineoplastic Agents
  • Biomarkers, Tumor