In vitro toxicological activity of particulate matter generated by coal combustion

Environ Toxicol Pharmacol. 2018 Dec:64:187-195. doi: 10.1016/j.etap.2018.11.003. Epub 2018 Nov 8.

Abstract

Herein, the toxicity of particles generated from the complete combustion of 1 g coal at 500, 700, and 900 °C were compared, and combustion at 700 °C generated the most toxins. Chemical analyses revealed that all components except catechol, resorcinol, and aromatic amines were most abundant at 700 °C. Toxicity results confirmed that the relative mutagenicity, cytotoxicity, redox cycling, and production of reactive oxygen species was highest for particles generated at 700 °C. Particles generated during combustion at 700 °C exhibited higher toxicity toward biological systems due to a higher content of toxic compounds.

Keywords: Coal combustion; Cytotoxicity; Mutagenicity; Reactive oxygen species; Redox cycling activity.

MeSH terms

  • A549 Cells
  • Air Pollutants / toxicity*
  • Amines / toxicity
  • Cell Survival / drug effects
  • Coal*
  • Humans
  • Hydrocarbons, Aromatic / toxicity
  • Mutagens / toxicity*
  • Particulate Matter / toxicity*
  • Power Plants
  • Reactive Oxygen Species / metabolism
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Temperature

Substances

  • Air Pollutants
  • Amines
  • Coal
  • Hydrocarbons, Aromatic
  • Mutagens
  • Particulate Matter
  • Reactive Oxygen Species