The BDNF Val66Met Polymorphism Promotes Changes in the Neuronal Integrity and Alters the Time Perception

J Mol Neurosci. 2019 Jan;67(1):82-88. doi: 10.1007/s12031-018-1212-1. Epub 2018 Nov 17.


Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the synchronization ability and brain oscillations in time perception. Genetic variation as a modifying factor at cellular and neurochemical levels permeates several neurofunctional aspects in time-lapse duration concentrating from milliseconds to hours. Thus, the review presents the BDNF Val66Met polymorphism association in a dynamic frame of brain neurotrophic factor expression in the adaptation, integrity, and neuronal synchronism processes in the ability to estimate multisensory stimuli at different time intervals. Our study aims to understand the molecular aspects involved in a neurobiological domain pertinent to the time judgment, tracing a genetic profile of association with psychometric functions and behavioral performances related to timing stimuli.

Keywords: BDNF Val66Met; BDNF gene; Neurobiological aspects; Time perception.

Publication types

  • Review

MeSH terms

  • Brain-Derived Neurotrophic Factor / genetics*
  • Cortical Synchronization / genetics
  • Humans
  • Polymorphism, Single Nucleotide*
  • Time Perception*


  • Brain-Derived Neurotrophic Factor
  • BDNF protein, human