Temporal variations of nucleosides and nucleotides in rabbit milk

Nucleosides Nucleotides Nucleic Acids. 2018;37(8):415-435. doi: 10.1080/15257770.2018.1494278. Epub 2018 Nov 17.


Nucleotides and nucleosides have a preeminent role in physiological and biochemical processes for newborns, the major source of these during early development is the breast milk. Different biomolecules exhibit daily fluctuations in maternal milk that could transfer temporal information that synchronize newborn circadian system. As a first approach, we characterized the diurnal profile of nucleotides and nucleosides contained in maternal milk of rabbits during the first week of lactation. It is possible that some nucleosides, such as adenosine, play a relevant role in setting up the emerging circadian rhythmicity, whereas uridine and guanosine could participate in the maintenance of rhythmicity.

Keywords: Circadian rhythms; maternal cyclical cues; maternal milk; nucleoside and nucleotide profiles.

MeSH terms

  • Analysis of Variance
  • Animals
  • Chromatography, High Pressure Liquid
  • Circadian Rhythm
  • Female
  • Lactation
  • Milk / chemistry*
  • Milk / physiology*
  • Nucleosides / analysis*
  • Nucleotides / analysis*
  • Photoperiod
  • Rabbits


  • Nucleosides
  • Nucleotides