Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force

Lauren C Harte-Hargrove; Aristea S Galanopoulou; Jacqueline A French; Asla Pitkänen; Vicky Whittemore; Helen E Scharfman

doi:10.1002/epi4.12234

Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force

Epilepsia Open. 2018 Jul 26;3(Suppl Suppl 1):13-23. doi: 10.1002/epi4.12234. eCollection 2018 Nov.

Authors

Lauren C Harte-Hargrove¹, Aristea S Galanopoulou², Jacqueline A French³, Asla Pitkänen⁴, Vicky Whittemore⁵, Helen E Scharfman⁶

Affiliations

¹ ILAE/AES Joint Translational Task Force U.S.A.
² Saul R. Korey Department of Neurology Dominick P. Purpura Department of Neuroscience Albert Einstein College of Medicine Bronx New York U.S.A.
³ Department of Neurology New York University New York New York U.S.A.
⁴ Epilepsy Research Laboratory A.I. Virtänen Institute for Molecular Sciences University of Eastern Finland Kuopio Finland.
⁵ National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland U.S.A.
⁶ The Nathan Kline Institute for Psychiatric Research Orangeburg New York U.S.A.

Abstract

Common data elements (CDEs) are becoming more common as more areas of preclinical research have generated CDEs. Herein we provide an overview of the progress to date in generating CDEs for preclinical epilepsy research. Currently there are CDEs that have been developed for Physiology (in vivo), Behavior, Pharmacology, and Electroencephalography (EEG). Together the CDEs and methodologic considerations associated with these CDEs are laid out in consecutive manuscripts published in Epilepsia Open, each describing CDEs for their respective topic area. In addition to the overview of progress for the 4 subjects, core characteristics (Core CDEs) are described and explained. Data collection using a case report form (CRF) is described, and considerations that are involved in using the CDEs and CRFs are discussed.

Keywords: Case report form; Reproducibility; Rigor; Translation; Transparency.

Abstract

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