Modelling knowledge and medical reasoning can be an epistemological project especially now, as medicine seems to reach a scientific status. Through his work on semiotics, abductive reasoning and pragmatism, CS Peirce (1839-1914) offers a series of original solutions. These solutions can give an account of (be considered as a theorical ground for) most of the medical activity in various fields such as the evaluation of the students, the knowledge bases and expert systems, the formal descriptions languages (ontologies), and the evidence-based medicine. By mean of this article, we aim at introducing the medical doctors to this complex but lighting thought on a profession which now uses all the most modern resources of knowledge engineering.
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