Tubulointerstitial Nephritis

Pediatr Clin North Am. 2019 Feb;66(1):111-119. doi: 10.1016/j.pcl.2018.08.009.


Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. The long-term prognosis is generally favorable, with full kidney recovery; however, some patients may develop progressive chronic kidney disease. Immunosuppressive therapy may be indicated for severe or prolonged disease.

Keywords: Acute interstitial nephritis; Acute kidney injury; Tubulointerstitial nephritis; Tubulointerstitial nephritis with uveitis.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Child
  • Diagnosis, Differential
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Nephritis, Interstitial / diagnosis*
  • Nephritis, Interstitial / drug therapy*
  • Nephritis, Interstitial / etiology


  • Adrenal Cortex Hormones
  • Immunosuppressive Agents