The molecular heterogeneity of protein kinase C and its implications for cellular regulation

Nature. 1988 Aug 25;334(6184):661-5. doi: 10.1038/334661a0.


Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics. Some members of the family exhibit distinct patterns of tissue expression and intracellular localization; different kinases probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Physiological Phenomena*
  • Gene Expression Regulation
  • Kinetics
  • Protein Kinase C / genetics
  • Protein Kinase C / physiology*
  • Tissue Distribution


  • Protein Kinase C