Flare of eosinophilic granulomatosis with polyangiitis related to pregnancy: Case report and review of the literature

Respir Med Case Rep. 2018 Nov 4;26:23-26. doi: 10.1016/j.rmcr.2018.10.027. eCollection 2019.


Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by excessive eosinophil accumulation in the peripheral blood and affected tissues with development of granulomatous vasculitic organ damage. It is strongly associated with asthma and ear-nose-throat disease. It often affects patients between the ages of 40 and 60 years. It is unknown whether pregnancy impacts the disease activity of EGPA, including initial diagnosis or relapse. Because of its rarity and age of susceptibility, there are few reported cases describing pregnancy in women with quiescent or active EGPA. Here, we describe a young woman who experienced EGPA relapse during pregnancy and subsequently underwent an elective caesarean section for non-reassuring fetal status at 37 weeks without complication.

Keywords: CNS, central nervous system; EGPA, eosinophilic granulomatosis with polyangiitis; Elective caesarean section; Eosinophilic granulomatosis with polyangiitis; IVIG, intravenous immunoglobulin; MPO-ANCA, anti-neutrophil cytoplasmic antibodies against myeloperoxidase; Non-reassuring fetal status; Pregnancy; Relapse.

Publication types

  • Case Reports