Gamma Knife radiosurgery for glomus tumors: Long-term results in a series of 30 patients

Head Neck. 2018 Dec;40(12):2677-2684. doi: 10.1002/hed.25517. Epub 2018 Nov 20.


Background: Glomus tumors are rare and benign hypervascular tumors. Surgery represented the mainstay of their treatment, even if it has been associated with high morbidity and mortality rates. Recently, the treatment shifted to a multimodal approach and Gamma Knife radiosurgery represents one of the treatment options.

Methods: Authors retrospectively analyzed the clinical and radiological outcome of a series of patients who underwent Gamma Knife radiosurgery for glomus tumors.

Results: Thirty patients underwent Gamma Knife radiosurgery. Mean tumor volume was 7.69 cc (range 0.36-24.6). Mean tumor margin dose was 16 Gy (range 13-18). Median follow-up was of 91 months (mean 90; range 11-172). Overall clinical control rate was 100%; overall volumetric tumor control rate was 96.6%. Patients' and tumors' characteristics, treatment data, and outcome have been analyzed.

Conclusion: Gamma Knife radiosurgery represents a safe and effective treatment for glomus tumors. Longer follow-up and larger cohort studies are needed to definitively outline the role of Gamma Knife radiosurgery for glomus tumors.

Keywords: Gamma Knife; chemodectoma; glomus tumor; radiosurgery; skull base.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Glomus Tumor / diagnostic imaging
  • Glomus Tumor / radiotherapy*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Radiation Dosage
  • Radiosurgery*
  • Retrospective Studies
  • Skull Base / diagnostic imaging
  • Skull Base Neoplasms / diagnostic imaging
  • Skull Base Neoplasms / radiotherapy*
  • Treatment Outcome