Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak

Euro Surveill. 2018 Nov;23(46):1800590. doi: 10.2807/1560-7917.ES.2018.23.46.1800590.

Abstract

Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011-12 among susceptible young children raises concern of another impending severe outbreak.

Keywords: Enteroviruses; Vietnam; enterovirus A71; foot and mouth disease; hand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Disease Outbreaks*
  • Enterovirus A, Human / classification
  • Enterovirus A, Human / genetics
  • Enterovirus A, Human / isolation & purification*
  • Enterovirus Infections / diagnosis
  • Enterovirus Infections / epidemiology*
  • Epidemics
  • Female
  • Genome, Viral / genetics*
  • Hand, Foot and Mouth Disease / epidemiology*
  • Hand, Foot and Mouth Disease / genetics
  • Hand, Foot and Mouth Disease / virology*
  • Hospitalization / statistics & numerical data*
  • Humans
  • Infant
  • Male
  • Sequence Analysis, RNA
  • Vietnam / epidemiology