Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018;157:663-675.
doi: 10.1016/B978-0-444-64074-1.00039-2.

Neuroleptic Malignant Syndrome and Serotonin Syndrome


Neuroleptic Malignant Syndrome and Serotonin Syndrome

Laura M Tormoehlen et al. Handb Clin Neurol. .


The clinical manifestation of drug-induced abnormalities in thermoregulation occurs across a variety of drug mechanisms. The aim of this chapter is to review two of the most common drug-induced hyperthermic states, serotonin syndrome and neuroleptic malignant syndrome. Clinical features, pathophysiology, and treatment strategies will be discussed, in addition to differentiating between these two syndromes and differentiating them from other hyperthermic or febrile syndromes. Our goal is to both review the current literature and to provide a practical guide to identification and treatment of these potentially life-threatening illnesses. The diagnostic and treatment recommendations made by us, and by other authors, are likely to change with a better understanding of the pathophysiology of these syndromes.

Keywords: bromocriptine; cyproheptadine; dantrolene; hyperthermia; malignant catatonia; neuroleptic malignant syndrome; serotonin syndrome.

Similar articles

See all similar articles

Cited by 1 article

MeSH terms

LinkOut - more resources