Sensing danger through a "finger"

Xiaojing Ma

doi:10.1084/jem.20182034

Sensing danger through a "finger"

J Exp Med. 2018 Dec 3;215(12):2969-2971. doi: 10.1084/jem.20182034. Epub 2018 Nov 20.

Author

Xiaojing Ma^{1

2}

Affiliations

¹ Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY xim2002@med.cornell.edu.
² Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, China.

Abstract

In this issue of JEM, the study by Chen et al. (https://doi.org/10.1084/jem.20181031) reveals a previously unrecognized role of cellular nucleic acid-binding protein (Cnbp) as a novel transcriptional regulator of interleukin-12β (IL-12β) transcription and IL-12-driven, Th1-mediated immune responses, which has important implications for both host defense and inflammatory disease.

Publication types

Comment

MeSH terms

Interleukin-12
Protein Transport
Signal Transduction*
Transcription Factors*
Transcription, Genetic

Substances

Transcription Factors
Interleukin-12